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NFL Picks Against the Spread (ATS) for Week 18

San Francisco will be a two-touchdown favorite in its regular-season finale against Arizona, in a game that could have little or no impact on its playoff seed.

As we enter Week 18 of the NFL season, another element has been added to the already fickle exercise that is picking games against the spread. While there is still plenty left to be determined when it comes to playoff seeding and draft positioning, the outcomes of earlier games could have a bearing on how other teams approach this final contest of the regular season.

Related: Expert Picks for Every Week 18 NFL Game

In other words, while only a few teams have come out and said they are resting their starters (New York Giants, for example) because their seed is already locked in, that doesn't mean this won't change (or coaches pull their starters early) depending on how some of these games play out. And there's also the ongoing debate about teams on the opposite end of the spectrum when a win is actually a "loss" as it relates to draft positioning. (How can you tell a team is tanking when it doesn't say it's tanking?)

So put all of these factors together and it adds even more potential variables for this week's spread picks. Oh, and did I mention that two more double-digit favorites failed to cover (again) last week?

Here's how Athlon's own Steven Lassan (@AthlonSteven), Mark Ross (@AthlonMarkR), and Ben Weinrib (@benweinrib), along with AthlonSports.com contributor Bryan Fischer (@BryanDFischer) see Week 18 playing out when it comes to picking against the spread.

NFL Week 18 Picks Against the Spread

SpreadBryan FischerSteven LassanMark RossBen Weinrib

Kansas City at Las Vegas (Sat.)

KC -9.5

Raiders

Chiefs

Raiders

Chiefs

Tennessee at Jacksonville (Sat.)

JAC -6

Jaguars

Jaguars

Jaguars

Jaguars

Tampa Bay at Atlanta

ATL -4

Falcons

Falcons

Falcons

Buccaneers

New England at Buffalo

BUF -7

Bills

Bills

Bills

Bills

Minnesota at Chicago

MIN -7.5

Bears

Vikings

Vikings

Vikings

Baltimore at Cincinnati

CIN -7

Bengals

Bengals

Bengals

Ravens

Houston at Indianapolis

IND -2.5

Colts

Colts

Texans

Colts

New York Jets at Miami

NYJ -1

Dolphins

Dolphins

Jets

Dolphins

Carolina at New Orleans

NO -3.5

Panthers

Saints

Saints

Panthers

Cleveland at Pittsburgh

PIT -2.5

Steelers

Steelers

Steelers

Browns

Los Angeles Chargers at Denver

DEN -2

Broncos

Chargers

Chargers

Chargers

New York Giants at Philadelphia

PHI -14

Giants

Giants

Giants

Eagles

Arizona at San Francisco

SF -14

Cardinals

49ers

49ers

49ers

Los Angeles Rams at Seattle

SEA -6

Seahawks

Seahawks

Seahawks

Rams

Dallas at Washington

DAL -7

Cowboys

Cowboys

Cowboys

Cowboys

Detroit at Green Bay (SNF)

GB -4.5

Packers

Packers

Packers

Lions

Week 17*

6-9

7-8

7-8

8-7

Season Total*

112-137

117-132

120-129

118-131

*Week 4's Bills-Ravens (Bills -3, 23-20), Week 5's Bears-Vikings (Vikings -7, 29-22), Week 9's Chargers-Falcons (Chargers -3, 20-17) and Rams-Buccaneers (Bucs -3, 16-13), Week 11's Bears-Falcons (Falcons -3, 27-24), and Week 15's Titans-Chargers (Chargers -3, 17-14) games are not counted in the season total because they were all pushes based on spreads. The Week 17 Bills-Bengals game that was postponed won't be resumed so it's also not included.