Chargers and Colts on Monday Night: Odds, Picks, and Betting Predictions for Week 16

"Monday Night Football" is always a special occasion, and this week's matchup between the Indianapolis Colts and Los Angeles Chargers is no exception. The Chargers come into Week 16 on a two-game win streak with an 8-6 record while the Colts have lost four straight and sit at 4-9-1.

Los Angeles is currently the sixth seed in the AFC playoff picture while the Colts have officially been eliminated since the Jaguars won their Week 16 matchup on Thursday night against the Jets. Indianapolis has had a tumultuous season, to say the least. Mid-way through the year they fired their offensive coordinator, then fired head coach Frank Reich, hired Jeff Saturday who previously had zero coaching experience, benched Matt Ryan, brought Ryan back as the starter, and now benched him again and plan on starting Nick Foles… WHEW. That’s enough drama to last a few seasons, let alone a few months. No wonder the Chargers are favored by 4.5 points on the road!

Chargers vs. Colts Odds, Point Spread, Moneyline, Point Total:

Spread: Chargers -4.5 (-110) | Colts +4.5 (-110)

Moneyline: Chargers (-213) | Colts (+175)

Point Total: Over 45.5 (-110) | Under 45.5 (-110)

Point Spread Prediction

The Chargers come into this game with an 8-5-1 record against the spread (ATS), while the Colts are 6-8. The Chargers have been particularly strong on the road, going 5-2 ATS in away games. They have also been successful as an away favorite, with a 3-1 ATS record in those games. The Colts, on the other hand, are 3-3 ATS at home and 2-0 ATS as a home underdog.

Bet: Chargers -4.5

Over/Under Point Total Prediction

The over has cashed in just five of the Colts' and Chargers' games this season, so those betting on the under may want to pay close attention to this matchup.

Bet: Under 45.5

Chargers Offense vs. Colts Defense

The Chargers have the advantage on offense, averaging 22.3 points per game, which ranks 14th in the league. They also have a potent passing attack, ranking second in the NFL with 274.2 passing yards per game. Justin Herbert (4,019 yards) trails Patrick Mahomes (4,496) by about 400 yards.

However, the Colts' defense has been solid against the pass, allowing just 205 yards per game, which ranks 10th in the league. They will need to continue this trend against the Chargers' high-powered passing attack if they want to snap their four-game losing streak.

Colts Offense vs. Chargers Defense

On the other side of the ball, the Colts have struggled offensively, ranking 29th in points per game with an average of 17.5. They have also struggled in terms of yards per pass attempt (5.9) and yards per carry (4.0), ranking 29th and 27th in the league, respectively. That could get even worse after Week 16 as Indianapolis will be without star running back Jonathan Taylor and has turned the quarterback duties over to backup Nick Foles.

The Chargers' defense, while not a strength of the team, has allowed 24.3 points per game, which is 25th in the NFL. However, they’ve played much better lately holding both of their opponents the last two weeks to less than 20 points.

Bottom Line

Overall, the Chargers have the edge in this matchup based on their strong ATS record and success as an away favorite. However, the Colts have shown they can be a tough opponent at home, especially as an underdog. This should be a closely contested game, and bettors will want to do their own research before making a final decision.